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TAF6L Antibody

CAT: 0223-60-381Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-381Size:400 µL
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Background
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation.
NCBI Gene ID
10629
Swiss Prot
Q9Y6J9
Accession Number
Q9Y6J9
Host
Rabbit
Reactivity
Human
Immunogen
This TAF6L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-103 amino acids from the N-terminal region of human TAF6L.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TAF6L
NCBI Official Name
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
NCBI Organism
Homo sapiens
Background Reference 01
Clarke, D.L., et al. J. Immunol. 181 (5) :3503-3514 (2008)
Background Reference 02
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Background Reference 03
Lim, J., et al. Cell 125 (4) :801-814 (2006)
Background Reference 04
Pitkanen, J., et al. Biochem. Biophys. Res. Commun. 333 (3) :944-953 (2005)
Other Product Names
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L, PCAF-associated factor 65-alpha, PAF65-alpha, TAF6L, PAF65A
Tested Applications
WB
Protein ID
46577572
Physical Properties
Liquid

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