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NR1H4 Antibody

CAT: 0223-60-257Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-257Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NR1H4 is a Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP) . Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
NCBI Gene ID
9971
Swiss Prot
Q96RI1
Accession Number
Q96RI1
Host
Rabbit
Reactivity
Human
Immunogen
This NR1H4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human NR1H4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NR1H4
NCBI Official Name
Bile acid receptor
NCBI Organism
Homo sapiens
Background Reference 01
Meyer Zu Schwabedissen, H.E., et al. Hepatology 52 (5) :1797-1807 (2010)
Background Reference 02
Popescu, I.R., et al. FEBS Lett. 584 (13) :2845-2851 (2010)
Background Reference 03
Gadaleta, R.M., et al. Biochim. Biophys. Acta 1801 (7) :683-692 (2010)
Background Reference 04
Roberts, K.E., et al. Gastroenterology 139 (1) :130-139 (2010)
Other Product Names
Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14, NR1H4, BAR, FXR, HRR1, RIP14
Tested Applications
WB
Protein ID
46577705
Physical Properties
Liquid

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