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MCF2L Antibody

CAT: 0223-60-130Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-130Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity) . Isoform 5 activates CDC42.
NCBI Gene ID
23263
Swiss Prot
O15068
Accession Number
O15068
Host
Rabbit
Reactivity
Human
Immunogen
This MCF2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1075 amino acids from the C-terminal region of human MCF2L.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
128 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MCF2L
NCBI Official Name
Guanine nucleotide exchange factor DBS
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Takefuji, M., et al. J. Hum. Genet. 55 (1) :42-49 (2010)
Background Reference 03
Ieguchi, K., et al. J. Biol. Chem. 282 (32) :23296-23305 (2007)
Background Reference 04
Yang, Q., et al. BMC Med. Genet.SUPPL 1, S12 (2007) :
Other Product Names
Guanine nucleotide exchange factor DBS, DBL's big sister, MCF2-transforming sequence-like protein, MCF2L, KIAA0362
Tested Applications
WB
Physical Properties
Liquid

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