DPH2 Antibody

• Background:

  This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1802

• Swiss Prot:

  Q9BQC3

• Accession Number:

  Q9BQC3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-148 amino acids from the N-terminal region of human DPH2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  52 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DPH2

• NCBI Official Name:

  Diphthamide biosynthesis protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J. Phd, et al. Mol. Med. (2010) In press :

• Background Reference 02:

  Liu, S., et al. Mol. Cell. Biol. 24 (21) :9487-9497 (2004)

• Background Reference 03:

  Schultz, D.C., et al. Genomics 52 (2) :186-191 (1998)

• Background Reference 04:

  Foley, B.T., et al. J. Biol. Chem. 270 (39) :23218-23225 (1995)

• Other Product Names:

  Diphthamide biosynthesis protein 2, DPH2 homolog, HsDph2, Diphthamide biosynthesis protein 2 homolog-like 2, DPH2-like 2, DPH2, DPH2L2

• Tested Applications:

  WB

• Protein ID:

  74761201

• Physical Properties:

  Liquid