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HMGCL Antibody

CAT: 0223-59-669Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-669Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
NCBI Gene ID
3155
Swiss Prot
P35914
Accession Number
P35914
Host
Rabbit
Reactivity
Human
Immunogen
This HMGCL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-99 amino acids from the N-terminal region of human HMGCL.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HMGCL
NCBI Official Name
Hydroxymethylglutaryl-CoA lyase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Fu, Z., et al. J. Biol. Chem. 285 (34) :26341-26349 (2010)
Background Reference 02
Pierron, S., et al. Arch Pediatr 17 (1) :10-13 (2010)
Background Reference 03
Menao, S., et al. Hum. Mutat. 30 (3), E520-E529 (2009) :
Background Reference 04
Lin, W.D., et al. Clin. Chim. Acta 401 (1-2), 33-36 (2009) :
Other Product Names
Hydroxymethylglutaryl-CoA lyase, mitochondrial, HL, HMG-CoA lyase, 3-hydroxy-3-methylglutarate-CoA lyase, HMGCL
Tested Applications
WB
Protein ID
24418852
Physical Properties
Liquid

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