GTF2I Antibody

• Background:

  This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7, 13 and 21.

• NCBI Gene ID:

  2969

• Swiss Prot:

  P78347

• Accession Number:

  P78347

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GTF2I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-310 amino acids from the N-terminal region of human GTF2I.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  112 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GTF2I

• NCBI Official Name:

  General transcription factor II-I

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Antonell, A., et al. J. Med. Genet. 47 (5) :312-320 (2010)

• Background Reference 02:

  Lazebnik, M.B., et al. J. Biol. Chem. 284 (52) :36234-36239 (2009)

• Background Reference 03:

  Sacristan, C., et al. Eur. J. Immunol. 39 (9) :2584-2595 (2009)

• Background Reference 04:

  Makeyev, A.V., et al. Gene 433 (1-2), 16-25 (2009) :

• Other Product Names:

  General transcription factor II-I, GTFII-I, TFII-I, Bruton tyrosine kinase-associated protein 135, BAP-135, BTK-associated protein 135, SRF-Phox1-interacting protein, SPIN, Williams-Beuren syndrome chromosomal region 6 protein, GTF2I, BAP135, WBSCR6

• Tested Applications:

  WB, IF

• Protein ID:

  17865459

• Physical Properties:

  Liquid