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HLA-C Antibody

CAT: 0223-59-490Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-490Size:400 µL
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Background
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin) . The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
NCBI Gene ID
3107
Swiss Prot
P10321
Accession Number
P10321
Host
Rabbit
Reactivity
Human
Immunogen
This HLA-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 amino acids from the Central region of human HLA-C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
HLA-C
NCBI Official Name
HLA class I histocompatibility antigen, Cw-7 alpha chain
NCBI Organism
Homo sapiens
Background Reference 01
Martin, M.P., et al. Immunogenetics 62 (11-12), 761-765 (2010) :
Background Reference 02
Strange, A., et al. Nat. Genet. 42 (11) :985-990 (2010)
Background Reference 03
Noble, J.A., et al. Diabetes 59 (11) :2972-2979 (2010)
Background Reference 04
Honeyborne, I., et al. J. Virol. 84 (21) :11279-11288 (2010)
Other Product Names
HLA class I histocompatibility antigen, Cw-7 alpha chain, MHC class I antigen Cw*7, HLA-C, HLAC
Tested Applications
WB
Protein ID
84028168
Physical Properties
Liquid

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