MPZL2 Antibody

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

10205

O60487

O60487

Human

This MPZL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human MPZL2.

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

24 kDa

Rabbit Ig

For WB starting dilution is: 1:1000

MPZL2

Myelin protein zero-like protein 2

Homo sapiens

Kim, H., et al. Pharmacogenomics 10 (2) :171-179 (2009)

Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

Clark, H.F., et al. Genome Res. 13 (10) :2265-2270 (2003)

Guttinger, M., et al. J. Cell Biol. 141 (4) :1061-1071 (1998)

Myelin protein zero-like protein 2, Epithelial V-like antigen 1, MPZL2, EVA, EVA1

WB