CD68/CD68 Antibody

CAT: 0223-59-170Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-59-170Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
NCBI Gene ID
968
Swiss Prot
P34810
Accession Number
P34810
Host
Rabbit
Reactivity
Human
Immunogen
This CD68/CD68 (kpi) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the Central region of human CD68/CD68 (kpi) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CD68
NCBI Official Name
Macrosialin
NCBI Organism
Homo sapiens
Background Reference 01
Leonarduzzi, G., et al. Mol Nutr Food Res 54 SUPPL 1, S31-S41 (2010) :
Background Reference 02
Strojnik, T., et al. Anticancer Res. 29 (8) :3269-3279 (2009)
Background Reference 03
Sayed, S., et al. EurVasc Endovasc Surg 38 (1) :20-25 (2009)
Background Reference 04
Suzuki, Y., et al. IntRheum Dis 12 (1) :7-13 (2009)
Other Product Names
Macrosialin, Gp110, CD68, CD68
Tested Applications
WB
Protein ID
147744552
Physical Properties
Liquid

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