CD68/CD68 Antibody

• Background:

  This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

• NCBI Gene ID:

  968

• Swiss Prot:

  P34810

• Accession Number:

  P34810

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD68/CD68 (kpi) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-237 amino acids from the Central region of human CD68/CD68 (kpi) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CD68

• NCBI Official Name:

  Macrosialin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leonarduzzi, G., et al. Mol Nutr Food Res 54 SUPPL 1, S31-S41 (2010) :

• Background Reference 02:

  Strojnik, T., et al. Anticancer Res. 29 (8) :3269-3279 (2009)

• Background Reference 03:

  Sayed, S., et al. EurVasc Endovasc Surg 38 (1) :20-25 (2009)

• Background Reference 04:

  Suzuki, Y., et al. IntRheum Dis 12 (1) :7-13 (2009)

• Other Product Names:

  Macrosialin, Gp110, CD68, CD68

• Tested Applications:

  WB

• Protein ID:

  147744552

• Physical Properties:

  Liquid