CD68 Recombinant Protein

• Background:

  CD68 is a single-pass type I membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells and in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

• NCBI Gene ID:

  968

• Swiss Prot:

  Q9Y6W8

• Accession Number:

  AAH15557

• Tag:

  Fc Tag

• Type:

  Recombinant Proteins

• Source:

  CHO cells

• Field of Research:

  Cancer, Immunology

• Buffer:

  Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μ l sterile water. Add 1X PBS to the desired protein concentration.

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

• Applications Notes:

  This recombinant proteins is for research use only.

• NCBI Official Name:

  CD68 molecule

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Macrosialin, GP110, Scavenger Receptor Class D Member 1, SCARD1

• Species:

  Human

• Protein ID:

  15990395

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3