EIF2B3 Antibody

• Background :

  The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  8891

• Swiss Prot :

  Q9NR50

• Accession Number :

  Q9NR50

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This EIF2B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 413-441 amino acids from the C-terminal region of human EIF2B3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  50 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  EIF2B3

• NCBI Official Name :

  Translation initiation factor eIF-2B subunit gamma

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Rose, J. Phd, et al. Mol. Med. (2010) In press :

• Background Reference 02 :

  Pronk, J., et al. Mult. Scler. 14 (8) :1123-1126 (2008)

• Background Reference 03 :

  Maletkovic, J., et al. J. Child Neurol. 23 (2) :205-215 (2008)

• Background Reference 04 :

  Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

• Other Product Names :

  Translation initiation factor eIF-2B subunit gamma, eIF-2B GDP-GTP exchange factor subunit gamma, EIF2B3

• Tested Applications :

  WB

• Protein ID :

  18203317

• Physical Properties :

  Liquid