MSH5 Antibody

• Background:

  This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms heterooligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants.

• NCBI Gene ID:

  4439

• Swiss Prot:

  O43196

• Accession Number:

  O43196

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MSH5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 525-552 amino acids from the Central region of human MSH5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  93 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MSH5

• NCBI Official Name:

  MutS protein homolog 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16 (10) :770-777 (2010)

• Background Reference 02:

  Pozo, N.D., et al. Hum. Immunol. 71 (9) :861-864 (2010)

• Background Reference 03:

  Snowden, T., et al. J. Biol. Chem. 283 (1) :145-154 (2008)

• Background Reference 04:

  Sekine, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104 (17) :7193-7198 (2007)

• Other Product Names:

  MutS protein homolog 5, hMSH5, MSH5

• Tested Applications:

  WB

• Physical Properties:

  Liquid