MSH2 Antibody

• Background:

  MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. [provided by RefSeq].

• NCBI Gene ID:

  4436

• Swiss Prot:

  P43246

• Accession Number:

  P43246

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MSH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the Central region of human MSH2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  105 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MSH2

• NCBI Official Name:

  DNA mismatch repair protein Msh2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, M., et al. Cancer Sci. 101 (11) :2436-2442 (2010)

• Background Reference 02:

  Mangoni, M., et al. Int. J. Radiat. Oncol. Biol. Phys. (2010) In press :

• Background Reference 03:

  Srivastava, K., et al. Cancer 116 (13) :3160-3169 (2010)

• Background Reference 04:

  Van der Post, R.S., et al. J. Med. Genet. 47 (7) :464-470 (2010)

• Other Product Names:

  DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2, MSH2

• Tested Applications:

  WB, IF, Flow

• Protein ID:

  1171032

• Physical Properties:

  Liquid