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PABPN1 Antibody

CAT: 0223-58-751Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-751Size:400 µL
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Background
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly (A) tails. The protein is required for progressive and efficient polymerization of poly (A) tails on the 3' ends of eukaryotic genes and controls the size of the poly (A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly (A) binding protein is localized in the cytoplasm. An expansion of the trinucleotide (GCG) repeat from normal 6 to 8-13 at the 5' end of the coding region of this gene leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Multiple splice variants have been described but their full-length nature is not known. One splice variant includes introns 1 and 6 but no protein is formed.
NCBI Gene ID
8106
Swiss Prot
Q86U42
Accession Number
Q86U42
Host
Rabbit
Reactivity
Human
Immunogen
This PABPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-298 amino acids from the C-terminal region of human PABPN1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PABPN1
NCBI Official Name
Polyadenylate-binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Hosgood, H.D. III, et al. Occup Environ Med 66 (12) :848-853 (2009)
Background Reference 02
Hurt, J.A., et al. J. Cell Biol. 185 (2) :265-277 (2009)
Background Reference 03
Kuo, H.C., et al. J. Neurol. Sci. 278 (1-2), 21-24 (2009) :
Background Reference 04
Tavanez, J.P., et al. PLoS ONE (7), E6418 (2009) :
Other Product Names
Polyadenylate-binding protein 2, PABP-2, Poly (A) -binding protein 2, Nuclear poly (A) -binding protein 1, Poly (A) -binding protein II, PABII, Polyadenylate-binding nuclear protein 1, PABPN1, PAB2, PABP2
Tested Applications
WB
Protein ID
46403176
Physical Properties
Liquid

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