PABPC1 Antibody

• Background:

  PABPC1 binds the poly (A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly (A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

• NCBI Gene ID:

  26986

• Swiss Prot:

  P11940

• Accession Number:

  P11940

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This PABPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-279 amino acids from the Central region of human PABPC1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  71 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PABPC1

• NCBI Official Name:

  Polyadenylate-binding protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Le Clerc, S., et.al., J. Infect. Dis. 200 (8), 1194-1201 (2009)

• Other Product Names:

  Polyadenylate-binding protein 1, PABP-1, Poly (A) -binding protein 1, PABPC1, PAB1, PABP1, PABPC2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  3183544

• Physical Properties:

  Liquid