PABPC1 Antibody

• Background:

  The poly (A) -binding protein (PABP), which is found complexed to the 3-prime poly (A) tail of eukaryotic mRNA, is required for poly (A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3 (PABPC3; MIM 604680) . In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.The poly (A) -binding protein (PABP), which is found complexed to the 3-prime poly (A) tail of eukaryotic mRNA, is required for poly (A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3 (PABPC3; MIM 604680) . In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.

• NCBI Gene ID:

  26986

• Swiss Prot:

  P11940

• Accession Number:

  NP_002559

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PABPC1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store PABPC1 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  71 kDa

• Applications Notes:

  PABPC1 antibody can be used for detection of PABPC1 by ELISA at 1:1562500. PABPC1 antibody can be used for detection of PABPC1 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  PABPC1

• NCBI Official Name:

  Poly (A) binding protein, cytoplasmic 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rivera, C.I. (2008) Virology 375 (1), 59-72.

• Other Product Names:

  PABPC1, PAB1, PABP, PABP1, PABPC2, PABPL1

• Tested Applications:

  ELISA, WB

• Protein ID:

  46367787

• Physical Properties:

  Liquid