MRGPRX2 Antibody

• Background:

  MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q) -coupled.

• NCBI Gene ID:

  117194

• Swiss Prot:

  Q96LB1

• Accession Number:

  Q96LB1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MRGPRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human MRGPRX2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction, Growth Factors

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MRGPRX2

• NCBI Official Name:

  Mas-related G-protein coupled receptor member X2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gembardt, F., et al. Mol. Cell. Biochem. 319 (1-2), 115-123 (2008) :

• Background Reference 02:

  Yang, S., et al. Gene 352, 30-35 (2005) :

• Background Reference 03:

  Robas, N., et al. J. Biol. Chem. 278 (45) :44400-44404 (2003)

• Background Reference 04:

  Takeda, S., et al. FEBS Lett. 520 (1-3), 97-101 (2002) :

• Other Product Names:

  Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2

• Tested Applications:

  WB

• Protein ID:

  50401127

• Physical Properties:

  Liquid