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MRGPRX2 Antibody

CAT: 0223-58-544Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-544Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q) -coupled.
NCBI Gene ID
117194
Swiss Prot
Q96LB1
Accession Number
Q96LB1
Host
Rabbit
Reactivity
Human
Immunogen
This MRGPRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human MRGPRX2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MRGPRX2
NCBI Official Name
Mas-related G-protein coupled receptor member X2
NCBI Organism
Homo sapiens
Background Reference 01
Gembardt, F., et al. Mol. Cell. Biochem. 319 (1-2), 115-123 (2008) :
Background Reference 02
Yang, S., et al. Gene 352, 30-35 (2005) :
Background Reference 03
Robas, N., et al. J. Biol. Chem. 278 (45) :44400-44404 (2003)
Background Reference 04
Takeda, S., et al. FEBS Lett. 520 (1-3), 97-101 (2002) :
Other Product Names
Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2
Tested Applications
WB
Protein ID
50401127
Physical Properties
Liquid

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