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ITGB7 Antibody

CAT: 0223-58-258Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-258Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) . Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
NCBI Gene ID
3695
Swiss Prot
P26010
Accession Number
P26010
Host
Rabbit
Reactivity
Human
Immunogen
This ITGB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the C-terminal region of human ITGB7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
87 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ITGB7
NCBI Official Name
Integrin beta-7
NCBI Organism
Homo sapiens
Background Reference 01
Cicala, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (49) :20877-20882 (2009)
Background Reference 02
Pentikainen, U., et al. J. Mol. Biol. 393 (3) :644-657 (2009)
Background Reference 03
Lad, Y., et al. J. Biol. Chem. 283 (50) :35154-35163 (2008)
Background Reference 04
Monteiro, P., et al. Biochem. Biophys. Res. Commun. 358 (2) :442-448 (2007)
Other Product Names
Integrin beta-7, Gut homing receptor beta subunit, ITGB7
Tested Applications
WB
Protein ID
124973
Physical Properties
Liquid

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