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ITGB2 Antibody

CAT: 0223-59-652Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-59-652Size:400 µL
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Background
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1) . Two transcript variants encoding the same protein have been identified for this gene.
NCBI Gene ID
3689
Swiss Prot
P05107
Accession Number
P05107
Host
Rabbit
Reactivity
Human
Immunogen
This ITGB2 antibody is generated from rabbits immunized with a recombinant protein from the human ITGB2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
85 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ITGB2
NCBI Official Name
Integrin beta-2
NCBI Organism
Homo sapiens
Background Reference 01
Gjelstrup, L.C., et al. J. Immunol. 185 (7) :4154-4168 (2010)
Background Reference 02
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 03
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 04
Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (33) :14727-14732 (2010)
Other Product Names
Integrin beta-2, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, CD18, ITGB2, CD18, MFI7
Tested Applications
WB
Protein ID
124056465
Physical Properties
Liquid

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