NR4A3 Antibody

• Background :

  This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE) . Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15) . Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID :

  8013

• Swiss Prot :

  Q92570

• Accession Number :

  Q92570

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This NR4A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human NR4A3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  68 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  NR4A3

• NCBI Official Name :

  Nuclear receptor subfamily 4 group A member 3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Novak, G., et al. Genes Brain Behav. 9 (8) :910-917 (2010)

• Background Reference 02 :

  Zhao, Y., et al. Circ. Res. 107 (4) :501-511 (2010)

• Background Reference 03 :

  Borup, R., et al. Endocr. Relat. Cancer 17 (3) :691-708 (2010)

• Background Reference 04 :

  Thompson, J., et al. Eur. J. Immunol. 40 (7) :2041-2049 (2010)

• Other Product Names :

  Nuclear receptor subfamily 4 group A member 3, Mitogen-induced nuclear orphan receptor, Neuron-derived orphan receptor 1, Nuclear hormone receptor NOR-1, NR4A3, CHN, CSMF, MINOR, NOR1, TEC

• Tested Applications :

  WB

• Protein ID :

  90110039

• Physical Properties :

  Liquid