NR4A2 Antibody

• Background:

  NR4A2 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. The protein may act as a transcription factor. Mutations in NR4A2 gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of NR4A2 gene may be associated with rheumatoid arthritis.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.

• NCBI Gene ID:

  4929

• Swiss Prot:

  P43354

• Accession Number:

  NP_006177

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog, Zebrafish, Drosophila

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NR4A2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Transcription, Cancer

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Cat. No. 1205 - Jurkat Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store NR4A2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  66 kDa, 64 kDa, 68 kDa, 64 kDa, 65 kDa, 60 kDa, 68 kDa, 70 kDa

• Applications Notes:

  NR4A2 antibody can be used for detection of NR4A2 by ELISA at 1:62500. NR4A2 antibody can be used for detection of NR4A2 by western blot at 0.25 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  NR4A2

• NCBI Official Name:

  Nuclear receptor subfamily 4, group A, member 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Holla, V.R., (2006) J. Biol. Chem. 281 (5), 2676-2682.

• Other Product Names:

  NR4A2, HZF-3, NOT, NURR1, RNR1, TINUR

• Tested Applications:

  ELISA, WB

• Protein ID:

  5453822

• Physical Properties:

  Liquid