TRIM27 Antibody

• Background :

  This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.

• NCBI Gene ID :

  5987

• Swiss Prot :

  P14373

• Accession Number :

  P14373

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This TRIM27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the C-terminal region of human TRIM27.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  58 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  TRIM27

• NCBI Official Name :

  Zinc finger protein RFP

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Johnson, A.D., et al. Nat. Genet. 42 (7) :608-613 (2010)

• Background Reference 02 :

  Barcellos, L.F., et al. PLoS Genet. (10), E1000696 (2009) :

• Background Reference 03 :

  Tezel, G.G., et al. Pathol. Res. Pract. 205 (6) :403-408 (2009)

• Background Reference 04 :

  Li, X., et al. Virology 360 (2) :419-433 (2007)

• Other Product Names :

  Zinc finger protein RFP, 632-, RING finger protein 76, Ret finger protein, Tripartite motif-containing protein 27, TRIM27, RFP, RNF76

• Tested Applications :

  WB

• Protein ID :

  132517

• Physical Properties :

  Liquid