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TRIM23 Antibody

CAT: 0223-57-172Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-172Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
NCBI Gene ID
373
Swiss Prot
P36406
Accession Number
P36406
Host
Rabbit
Reactivity
Human
Immunogen
This TRIM23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the N-terminal region of human TRIM23.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
64 kDa
Fragment
Rabbit Ig
Symbol
TRIM23
NCBI Official Name
E3 ubiquitin-protein ligase TRIM23
NCBI Organism
Homo sapiens
Background Reference 01
Arimoto, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (36) :15856-15861 (2010)
Background Reference 02
Poole, E., et al. J. Virol. 83 (8) :3581-3590 (2009)
Background Reference 03
Venkatesan, K., et al. Nat. Methods 6 (1) :83-90 (2009)
Background Reference 04
Vichi, A., et al. Proc. Natl. Acad. Sci. U.S.A. 102 (6) :1945-1950 (2005)
Other Product Names
E3 ubiquitin-protein ligase TRIM23, 632-, ADP-ribosylation factor domain-containing protein 1, GTP-binding protein ARD-1, RING finger protein 46, Tripartite motif-containing protein 23, TRIM23, ARD1, ARFD1, RNF46
Tested Applications
WB, IHC-P
Protein ID
543839
Physical Properties
Liquid

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