TRIM22 Antibody

• Background:

  The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.

• NCBI Gene ID:

  10346

• Swiss Prot:

  Q8IYM9

• Accession Number:

  Q8IYM9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRIM22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human TRIM22.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TRIM22

• NCBI Official Name:

  E3 ubiquitin-protein ligase TRIM22

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kajaste-Rudnitski, A., et al. Amino Acids 39 (1) :1-9 (2010)

• Background Reference 02:

  Petersson, J., et al. Exp. Cell Res. 316 (4) :568-579 (2010)

• Background Reference 03:

  Ovsyannikova, I.G., et al. Hum. Genet. 127 (2) :207-221 (2010)

• Background Reference 04:

  Ovsyannikova, I.G., et al. J. Infect. Dis. 201 (2) :207-213 (2010)

• Other Product Names:

  E3 ubiquitin-protein ligase TRIM22, 632-, 50 kDa-stimulated trans-acting factor, RING finger protein 94, Staf-50, Tripartite motif-containing protein 22, TRIM22, RNF94, STAF50

• Tested Applications:

  WB

• Protein ID:

  47606181

• Physical Properties:

  Liquid