HYAL1 Antibody

• Background:

  This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  3373

• Swiss Prot:

  Q12794

• Accession Number:

  Q12794

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HYAL1

• NCBI Official Name:

  Hyaluronidase-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lanktree, M.B., et al. Blood 116 (12) :2160-2163 (2010)

• Background Reference 02:

  Gasingirwa, M.C., et al. Biochem. J. 430 (2) :305-313 (2010)

• Background Reference 03:

  Tzuman, Y.C., et al. Neoplasia 12 (1) :51-60 (2010)

• Background Reference 04:

  Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :

• Other Product Names:

  Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  74735617

• Physical Properties:

  Liquid