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HYAL2 Antibody

CAT: 0223-55-374Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-374Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
NCBI Gene ID
8692
Swiss Prot
Q12891
Accession Number
Q12891
Host
Rabbit
Reactivity
Human
Immunogen
This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of human HYAL2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
HYAL2
NCBI Official Name
Hyaluronidase-2
NCBI Organism
Homo sapiens
Background Reference 01
Monzon, M.E., et al. J. Biol. Chem. 285 (34) :26126-26134 (2010)
Background Reference 02
Tzuman, Y.C., et al. Neoplasia 12 (1) :51-60 (2010)
Background Reference 03
De la Motte, C., et al. Am. J. Pathol. 174 (6) :2254-2264 (2009)
Background Reference 04
Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :
Other Product Names
Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2
Tested Applications
WB, IHC-P, Flow
Protein ID
311033483
Physical Properties
Liquid

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