HYAL2 Antibody

• Background:

  This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.

• NCBI Gene ID:

  8692

• Swiss Prot:

  Q12891

• Accession Number:

  Q12891

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HYAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-412 amino acids from the C-terminal region of human HYAL2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  HYAL2

• NCBI Official Name:

  Hyaluronidase-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Monzon, M.E., et al. J. Biol. Chem. 285 (34) :26126-26134 (2010)

• Background Reference 02:

  Tzuman, Y.C., et al. Neoplasia 12 (1) :51-60 (2010)

• Background Reference 03:

  De la Motte, C., et al. Am. J. Pathol. 174 (6) :2254-2264 (2009)

• Background Reference 04:

  Nykopp, T.K., et al. BMC Cancer 9, 143 (2009) :

• Other Product Names:

  Hyaluronidase-2, Hyal-2, Hyaluronoglucosaminidase-2, Lung carcinoma protein 2, LuCa-2, HYAL2, LUCA2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  311033483

• Physical Properties:

  Liquid