ALG11 Antibody

• Background:

  This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP) . This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19.

• NCBI Gene ID:

  440138

• Swiss Prot:

  Q2TAA5

• Accession Number:

  Q2TAA5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ALG11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-373 amino acids from the C-terminal region of human ALG11.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ALG11

• NCBI Official Name:

  GDP-Man:Man (3) GlcNAc (2) -PP-Dol alpha-1,2-mannosyltransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rind, N., et al. Hum. Mol. Genet. 19 (8) :1413-1424 (2010)

• Background Reference 02:

  Rohozinski, J., et al. Biol. Reprod. 74 (4) :644-651 (2006)

• Other Product Names:

  GDP-Man:Man (3) GlcNAc (2) -PP-Dol alpha-1,2-mannosyltransferase, Asparagine-linked glycosylation protein 11 homolog, Glycolipid 2-alpha-mannosyltransferase, ALG11, GT8

• Tested Applications:

  WB

• Protein ID:

  156631015

• Physical Properties:

  Liquid