SPI1 Antibody

• Background:

  This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  6688

• Swiss Prot:

  P17947

• Accession Number:

  P17947

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SPI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human SPI1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  31 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SPI1

• NCBI Official Name:

  Transcription factor PU.1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rimmele, P., et al. Cancer Res. 70 (17) :6757-6766 (2010)

• Background Reference 02:

  Bonadies, N., et al. Oncogene 29 (7) :1062-1072 (2010)

• Background Reference 03:

  Bonadies, N., et al. Blood 115 (2) :331-334 (2010)

• Background Reference 04:

  Desai, S., et al. J. Immunol. 183 (9) :5778-5787 (2009)

• Other Product Names:

  Transcription factor PU1, 31 kDa-transforming protein, SPI1

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  60415923

• Physical Properties:

  Liquid