Mouse Aurka Antibody

• Background:

  Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity) . Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.

• NCBI Gene ID:

  20878

• Swiss Prot:

  P97477

• Accession Number:

  P97477

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Aurka antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of mouse Aurka.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Aurka

• NCBI Official Name:

  Aurora kinase A

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Kinzel, D., et al. Dev. Cell 19 (1) :66-77 (2010)

• Background Reference 02:

  Van Horn, R.D., et al. J. Biol. Chem. 285 (28) :21849-21857 (2010)

• Background Reference 03:

  Mori, D., et al. Nat. Cell Biol. 11 (9) :1057-1068 (2009)

• Background Reference 04:

  Li, C.C., et al. Mol. Cancer Res. 7 (5) :678-688 (2009)

• Other Product Names:

  Aurora kinase A, Aurora 2, Aurora family kinase 1, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, Ipl1- and aurora-related kinase 1, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase Ayk1, Serine/threonine-protein kinase aurora-A, Aurka

• Tested Applications:

  WB

• Physical Properties:

  Liquid