TNFSF14 Antibody

• Background:

  The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM) . This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

• NCBI Gene ID:

  8740

• Swiss Prot:

  O43557

• Accession Number:

  O43557

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TNFSF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the Central region of human TNFSF14.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  26 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TNFSF14

• NCBI Official Name:

  Tumor necrosis factor ligand superfamily member 14

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Stiles, K.M., et al. J. Virol. 84 (22) :11646-11660 (2010)

• Background Reference 02:

  Jin, H.R., et al. Biochem. Biophys. Res. Commun. 400 (4) :581-586 (2010)

• Background Reference 03:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 04:

  Cheung, T.C., et al. J. Immunol. 185 (3) :1949-1958 (2010)

• Other Product Names:

  Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, CD258, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form, TNFSF14, HVEML, LIGHT

• Tested Applications:

  WB

• Physical Properties:

  Liquid