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TNFSF14 Antibody

CAT: 0223-57-843Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-843Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM) . This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
NCBI Gene ID
8740
Swiss Prot
O43557
Accession Number
O43557
Host
Rabbit
Reactivity
Human
Immunogen
This TNFSF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the Central region of human TNFSF14.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
26 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TNFSF14
NCBI Official Name
Tumor necrosis factor ligand superfamily member 14
NCBI Organism
Homo sapiens
Background Reference 01
Stiles, K.M., et al. J. Virol. 84 (22) :11646-11660 (2010)
Background Reference 02
Jin, H.R., et al. Biochem. Biophys. Res. Commun. 400 (4) :581-586 (2010)
Background Reference 03
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 04
Cheung, T.C., et al. J. Immunol. 185 (3) :1949-1958 (2010)
Other Product Names
Tumor necrosis factor ligand superfamily member 14, Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, CD258, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form, TNFSF14, HVEML, LIGHT
Tested Applications
WB
Physical Properties
Liquid

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