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TNFSF10 Antibody

CAT: 0223-31-018Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-31-018Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
NCBI Gene ID
8743
Swiss Prot
P50591
Accession Number
NP_003801
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TNFSF10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Membrane, Cancer, Signal Transduction, Immunology, Apoptosis
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store TNFSF10 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
33 kDa
Applications Notes
TNFSF10 antibody can be used for detection of TNFSF10 by ELISA at 1:62500. TNFSF10 antibody can be used for detection of TNFSF10 by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
TNFSF10
NCBI Official Name
Tumor necrosis factor (ligand) superfamily, member 10
NCBI Organism
Homo sapiens
Background Reference 01
Wu, Y.Y., et al., (2004) World J. Gastroenterol. 10 (16), 2334-2339.
Other Product Names
TNFSF10, TL2, APO2L, CD253, TRAIL, Apo-2L
Tested Applications
ELISA, WB
Protein ID
4507593
Physical Properties
Liquid

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MBS8516331-01TNFSF10 Antibody

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