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MCM4 Antibody

CAT: 0223-57-795Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-795Size:400 µL
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Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
NCBI Gene ID
4173
Swiss Prot
P33991
Accession Number
P33991
Host
Rabbit
Reactivity
Human
Immunogen
This MCM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 637-665 amino acids from the C-terminal region of human MCM4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Xenopus, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
97 kDa
Fragment
Rabbit Ig
Symbol
MCM4
NCBI Official Name
DNA replication licensing factor MCM4
NCBI Organism
Homo sapiens
Background Reference 01
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 02
Qian, Z., et al. PLoS Pathog. (3), E1000814 (2010) :
Background Reference 03
Ladstein, R.G., et al. BMC Cancer 10, 140 (2010) :
Background Reference 04
Hosgood, H.D. III, et al. Occup Environ Med 66 (12) :848-853 (2009)
Other Product Names
DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21, MCM4, CDC21
Tested Applications
WB, IHC-P
Protein ID
68571766
Physical Properties
Liquid

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