Mouse Ptk2 Antibody

• Background :

  Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity) . Plays a potential role in oncogenic transformations resulting in increased kinase activity.

• NCBI Gene ID :

  14083

• Swiss Prot :

  P34152

• Accession Number :

  P34152

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This Mouse Ptk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-453 amino acids from the Central region of mouse Ptk2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  124 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  Ptk2

• NCBI Official Name :

  Focal adhesion kinase 1

• NCBI Organism :

  Mus musculus

• Background Reference 01 :

  Enciso, J.M., et al. Dev. Dyn. 239 (10) :2570-2583 (2010)

• Background Reference 02 :

  Beverdam, A., et al. Dev. Dyn. 239 (10) :2735-2741 (2010)

• Background Reference 03 :

  Ma, Y., et al. FEBS Lett. 584 (18) :3949-3954 (2010)

• Background Reference 04 :

  Beinke, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (37) :16234-16239 (2010)

• Other Product Names :

  Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein-tyrosine kinase 2, p125FAK, pp125FAK, Ptk2, Fadk, Fak, Fak1, Kiaa4203

• Tested Applications :

  WB

• Physical Properties :

  Liquid