Mouse Ptk2 Antibody

• Background:

  Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity) . Plays a potential role in oncogenic transformations resulting in increased kinase activity.

• NCBI Gene ID:

  14083

• Swiss Prot:

  P34152

• Accession Number:

  P34152

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Ptk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 426-453 amino acids from the Central region of mouse Ptk2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  124 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Ptk2

• NCBI Official Name:

  Focal adhesion kinase 1

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Enciso, J.M., et al. Dev. Dyn. 239 (10) :2570-2583 (2010)

• Background Reference 02:

  Beverdam, A., et al. Dev. Dyn. 239 (10) :2735-2741 (2010)

• Background Reference 03:

  Ma, Y., et al. FEBS Lett. 584 (18) :3949-3954 (2010)

• Background Reference 04:

  Beinke, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (37) :16234-16239 (2010)

• Other Product Names:

  Focal adhesion kinase 1, FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein-tyrosine kinase 2, p125FAK, pp125FAK, Ptk2, Fadk, Fak, Fak1, Kiaa4203

• Tested Applications:

  WB

• Physical Properties:

  Liquid