Mouse Pak4 Antibody

• Background:

  Pak4 activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates ARHGEF2 (By similarity) .

• NCBI Gene ID:

  70584

• Swiss Prot:

  Q8BTW9

• Accession Number:

  Q8BTW9

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Mouse Pak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-216 amino acids from the Central region of mouse Pak4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  65 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  Pak4

• NCBI Official Name:

  Serine/threonine-protein kinase PAK 4

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Liu, Y., et al. Oncogene 29 (44) :5883-5894 (2010)

• Background Reference 02:

  Tian, Y., et al. Mech. Dev. 126 (8-9), 710-720 (2009) :

• Background Reference 03:

  Ha, U.H., et al. J. Biol. Chem. 283 (45) :30624-30631 (2008)

• Background Reference 04:

  Liu, Y., et al. Mol. Cancer Res. 6 (7) :1215-1224 (2008)

• Other Product Names:

  Serine/threonine-protein kinase PAK 4, p21-activated kinase 4, PAK-4, Pak4, Kiaa1142

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid