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DSG1 Antibody

CAT: 0223-57-728Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-728Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
NCBI Gene ID
1828
Swiss Prot
Q02413
Accession Number
Q02413
Host
Rabbit
Reactivity
Human
Immunogen
This DSG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-499 amino acids from the Central region of human DSG1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
114 kDa
Fragment
Rabbit Ig
Symbol
DSG1
NCBI Official Name
Desmoglein-1
NCBI Organism
Homo sapiens
Background Reference 01
Rothenberg, M.E., et al. Nat. Genet. 42 (4) :289-291 (2010)
Background Reference 02
Naoe, Y., et al. J. Dermatol. Sci. 57 (3) :192-198 (2010)
Background Reference 03
Qian, Y., et al. J. Invest. Dermatol. 129 (12) :2823-2834 (2009)
Background Reference 04
Spindler, V., et al. J. Biol. Chem. 284 (44) :30556-30564 (2009)
Other Product Names
Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4
Tested Applications
WB, IHC-P
Protein ID
292495005
Physical Properties
Liquid

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