DSG2 Antibody

• Background :

  Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.

• NCBI Gene ID :

  1829

• Swiss Prot :

  Q14126

• Accession Number :

  Q14126

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This DSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 829-857 amino acids from the C-terminal region of human DSG2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  122 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  DSG2

• NCBI Official Name :

  Desmoglein-2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02 :

  Fressart, V., et al. Europace 12 (6) :861-868 (2010)

• Background Reference 03 :

  Schlegel, N., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (5), G774-G783 (2010) :

• Background Reference 04 :

  Cox, M.G., et al. Circ Arrhythm Electrophysiol 3 (2) :126-133 (2010)

• Other Product Names :

  Desmoglein-2, Cadherin family member 5, HDGC, DSG2, CDHF5

• Tested Applications :

  WB, IHC-P

• Protein ID :

  148876773

• Physical Properties :

  Liquid