METAP2 Antibody

• Background:

  This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.

• NCBI Gene ID:

  10988

• Swiss Prot:

  P50579

• Accession Number:

  P50579

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This METAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human METAP2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  METAP2

• NCBI Official Name:

  Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Xiao, Q., et al. Biochemistry 49 (26) :5588-5599 (2010)

• Background Reference 02:

  Wang, X., et al. PLoS ONE (8), E11934 (2010) :

• Background Reference 03:

  Selvakumar, P., et al. Mol. Cancer 8, 65 (2009) :

• Background Reference 04:

  Warder, S.E., et al. J. Proteome Res. 7 (11) :4807-4820 (2008)

• Other Product Names:

  Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}

• Tested Applications:

  WB

• Protein ID:

  1703273

• Physical Properties:

  Liquid