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METAP2 Antibody

CAT: 0223-57-699Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-699Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
NCBI Gene ID
10988
Swiss Prot
P50579
Accession Number
P50579
Host
Rabbit
Reactivity
Human
Immunogen
This METAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human METAP2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
53 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
METAP2
NCBI Official Name
Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}
NCBI Organism
Homo sapiens
Background Reference 01
Xiao, Q., et al. Biochemistry 49 (26) :5588-5599 (2010)
Background Reference 02
Wang, X., et al. PLoS ONE (8), E11934 (2010) :
Background Reference 03
Selvakumar, P., et al. Mol. Cancer 8, 65 (2009) :
Background Reference 04
Warder, S.E., et al. J. Proteome Res. 7 (11) :4807-4820 (2008)
Other Product Names
Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
Tested Applications
WB
Protein ID
1703273
Physical Properties
Liquid

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