UBA7 Antibody

• Background:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML) /retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq].

• NCBI Gene ID:

  7318

• Swiss Prot:

  P41226

• Accession Number:

  P41226

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the N-terminal region of human UBA7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  112 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  UBA7

• NCBI Official Name:

  Ubiquitin-like modifier-activating enzyme 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Fransen, K., et al. Hum. Mol. Genet. 19 (17) :3482-3488 (2010)

• Background Reference 02:

  Morgan, A.R., et al. Hum. Immunol. 71 (6) :602-609 (2010)

• Background Reference 03:

  Feng, Q., et al. Mol. Cancer Ther. 7 (12) :3780-3788 (2008)

• Background Reference 04:

  Durfee, L.A., et al. J. Biol. Chem. 283 (35) :23895-23902 (2008)

• Other Product Names:

  Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, D8, Ubiquitin-activating enzyme E1 homolog, UBA7, UBE1L, UBE2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  215273977

• Physical Properties:

  Liquid