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UBA7 Antibody

CAT: 0223-57-551Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-551Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML) /retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq].
NCBI Gene ID
7318
Swiss Prot
P41226
Accession Number
P41226
Host
Rabbit
Reactivity
Human
Immunogen
This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 amino acids from the N-terminal region of human UBA7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
112 kDa
Fragment
Rabbit Ig
Symbol
UBA7
NCBI Official Name
Ubiquitin-like modifier-activating enzyme 7
NCBI Organism
Homo sapiens
Background Reference 01
Fransen, K., et al. Hum. Mol. Genet. 19 (17) :3482-3488 (2010)
Background Reference 02
Morgan, A.R., et al. Hum. Immunol. 71 (6) :602-609 (2010)
Background Reference 03
Feng, Q., et al. Mol. Cancer Ther. 7 (12) :3780-3788 (2008)
Background Reference 04
Durfee, L.A., et al. J. Biol. Chem. 283 (35) :23895-23902 (2008)
Other Product Names
Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-activating enzyme 7, D8, Ubiquitin-activating enzyme E1 homolog, UBA7, UBE1L, UBE2
Tested Applications
WB, IHC-P
Protein ID
215273977
Physical Properties
Liquid

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