UBA3 Antibody

• Background:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

• NCBI Gene ID:

  9039

• Swiss Prot:

  Q8TBC4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 234-463 of human UBA3 (NP_003959.3) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cell Cycle

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 52kDa/104kDa

• Fragment:

  IgG

• Symbol:

  UBA3

• Positive Control 2:

  HeLa

• Positive Control 3:

  HepG2

• Positive Control 4:

  Jurkat

• Positive Control 5:

  HL-60

• Positive Control 6:

  Mouse brain

• NCBI Official Name:

  Ubiquitin-like modifier activating enzyme 3

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  UBA3, DKFZp566J164, MGC22384, UBE1C, hUBA3, NAE2

• Tested Applications:

  WB, IHC

• Physical Properties:

  Liquid