UBA3 Antibody

• Background :

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

• NCBI Gene ID :

  9039

• Swiss Prot :

  Q8TBC4

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant fusion protein containing a sequence corresponding to amino acids 234-463 of human UBA3 (NP_003959.3) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis, Cell Cycle

• Purification :

  Affinity purification

• Positive Control :

  293T

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 52kDa/104kDa

• Fragment :

  IgG

• Symbol :

  UBA3

• Positive Control 2 :

  HeLa

• Positive Control 3 :

  HepG2

• Positive Control 4 :

  Jurkat

• Positive Control 5 :

  HL-60

• Positive Control 6 :

  Mouse brain

• NCBI Official Name :

  Ubiquitin-like modifier activating enzyme 3

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  UBA3, DKFZp566J164, MGC22384, UBE1C, hUBA3, NAE2

• Tested Applications :

  WB, IHC

• Physical Properties :

  Liquid