CDH8 Antibody

• Background :

  CDH8 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.

• NCBI Gene ID :

  1006

• Swiss Prot :

  P55286

• Accession Number :

  P55286

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CDH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human CDH8.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  88 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CDH8

• NCBI Official Name :

  Cadherin-8

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Blaschke, S., Int. J. Cancer 101 (4), 327-334 (2002)

• Background Reference 02 :

  Shimoyama, Y., Biochem. J. 349 (PT 1), 159-167 (2000)

• Other Product Names :

  Cadherin-8, CDH8

• Tested Applications :

  WB, IHC-P

• Protein ID :

  13432121

• Physical Properties :

  Liquid