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CDH4 Antibody

CAT: 0223-57-420Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-420Size:400 µL
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Background
CDH4 is a classical cadherin from the cadherin superfamily. It is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
NCBI Gene ID
1002
Swiss Prot
P55283
Accession Number
P55283
Host
Rabbit
Reactivity
Human
Immunogen
This CDH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-203 amino acids from the N-terminal region of human CDH4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
100 kDa
Fragment
Rabbit Ig
Symbol
CDH4
NCBI Official Name
Cadherin-4
NCBI Organism
Homo sapiens
Background Reference 01
Miotto, E., Cancer Res. 64 (22), 8156-8159 (2004)
Background Reference 02
Johnson, E., J. Biol. Chem. 279 (30), 31041-31049 (2004)
Background Reference 03
Kitagawa, M., Biochem. Biophys. Res. Commun. 271 (2), 358-363 (2000)
Other Product Names
Cadherin-4, Retinal cadherin, R-CAD, R-cadherin, CDH4
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
81175161
Physical Properties
Liquid

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