CDH4 Antibody

CDH4 gene is a classical cadherin from the cadherin superfamily. The protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

1002

P55283

NP_001785

Human, Mouse, Rat

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CDH4.

Unconjugated

Primary Antibodies

Membrane, Cancer, Signal Transduction

Antibody is purified by peptide affinity chromatography method.

Cat. No. 1211 - HepG2 Cell Lysate

Batch dependent

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

None

Blue Ice

For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CDH4 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

82 kDa

CDH4 antibody can be used for detection of CDH4 by ELISA at 1:62500. CDH4 antibody can be used for detection of CDH4 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

CDH4

Cadherin 4, type 1, R-cadherin (retinal)

Homo sapiens

Maeda, M., (2006) Oncogene 25 (33), 4595-4604.

CDH4, CAD4, FLJ22202, FLJ40547, MGC126700, MGC138355, RCAD

ELISA, WB

14589893