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MCM3 Antibody

CAT: 0223-57-424Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-424Size:400 µL
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Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq].
NCBI Gene ID
4172
Swiss Prot
P25205
Accession Number
P25205
Host
Rabbit
Reactivity
Human
Immunogen
This MCM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-64 amino acids from the N-terminal region of human MCM3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
91 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MCM3
NCBI Official Name
DNA replication licensing factor MCM3
NCBI Organism
Homo sapiens
Background Reference 01
Lau, K.M., et al. Oncogene 29 (40) :5475-5489 (2010)
Background Reference 02
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 03
Lee, Y.S., et al. Exp. Mol. Pathol. 88 (1) :138-142 (2010)
Background Reference 04
Song, Y.J., et al. Acta Virol. 54 (2) :125-130 (2010)
Other Product Names
DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3
Tested Applications
WB
Protein ID
19857543
Physical Properties
Liquid

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