CUL4A Antibody

• Background:

  CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]) .

• NCBI Gene ID:

  8451

• Swiss Prot:

  Q13619

• Accession Number:

  Q13619

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CUL4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31-60 amino acids from the N-terminal region of human CUL4A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CUL4A

• NCBI Official Name:

  Cullin-4A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Aggarwal, P., et al. Cancer Cell 18 (4) :329-340 (2010)

• Background Reference 02:

  Abbas, T., et al. Mol. Cell 40 (1) :9-21 (2010)

• Background Reference 03:

  Lv, X.B., et al. J. Biol. Chem. 285 (24) :18234-18240 (2010)

• Background Reference 04:

  Kerzendorfer, C., et al. Hum. Mol. Genet. 19 (7) :1324-1334 (2010)

• Other Product Names:

  Cullin-4A, CUL-4A, CUL4A

• Tested Applications:

  WB

• Protein ID:

  108936013

• Physical Properties:

  Liquid