CUL4B Antibody

• Background:

  This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

• NCBI Gene ID:

  8450

• Swiss Prot:

  Q13620

• Accession Number:

  Q13620

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CUL4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the Central region of human CUL4B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  104 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CUL4B

• NCBI Official Name:

  Cullin-4B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Aggarwal, P., et al. Cancer Cell 18 (4) :329-340 (2010)

• Background Reference 02:

  Abbas, T., et al. Mol. Cell 40 (1) :9-21 (2010)

• Background Reference 03:

  Kerzendorfer, C., et al. Hum. Mol. Genet. 19 (7) :1324-1334 (2010)

• Background Reference 04:

  Gascoin-Lachambre, G., et al. Placenta 31 (2) :151-157 (2010)

• Other Product Names:

  Cullin-4B, CUL-4B, CUL4B, KIAA0695

• Tested Applications:

  WB

• Protein ID:

  296439468

• Physical Properties:

  Liquid