GDI2 Antibody

• Background:

  GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• NCBI Gene ID:

  2665

• Swiss Prot:

  P50395

• Accession Number:

  P50395

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GDI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the Central region of human GDI2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  51 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GDI2

• NCBI Official Name:

  Rab GDP dissociation inhibitor beta

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rikova, K., et al. Cell 131 (6) :1190-1203 (2007)

• Background Reference 02:

  Sun, Z.L., et al. Biochim. Biophys. Acta 1774 (6) :764-771 (2007)

• Background Reference 03:

  Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)

• Background Reference 04:

  Grupe, A., et al. Am. J. Hum. Genet. 78 (1) :78-88 (2006)

• Other Product Names:

  Rab GDP dissociation inhibitor beta, Rab GDI beta, Guanosine diphosphate dissociation inhibitor 2, GDI-2, GDI2, RABGDIB

• Tested Applications:

  WB, IHC-P

• Protein ID:

  13638228

• Physical Properties:

  Liquid