TRPC5 Antibody

• Background:

  This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na (+) -H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1) .

• NCBI Gene ID:

  7224

• Swiss Prot:

  Q9UL62

• Accession Number:

  Q9UL62

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRPC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-283 amino acids from the N-terminal region of human TRPC5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rabbit

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  111 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TRPC5

• NCBI Official Name:

  Short transient receptor potential channel 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Al-Shawaf, E., et al. Arterioscler. Thromb. Vasc. Biol. 30 (7) :1453-1459 (2010)

• Background Reference 02:

  Wong, C.O., et al. Pflugers Arch. 460 (1) :121-130 (2010)

• Background Reference 03:

  Miehe, S., et al. J. Biol. Chem. 285 (16) :12426-12434 (2010)

• Background Reference 04:

  Gross, S.A., et al. J. Biol. Chem. 284 (49) :34423-34432 (2009)

• Other Product Names:

  Short transient receptor potential channel 5, TrpC5, Transient receptor protein 5, TRP-5, hTRP-5, hTRP5, TRPC5, TRP5

• Tested Applications:

  WB, IHC-P

• Protein ID:

  10720321

• Physical Properties:

  Liquid