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PPP4C Antibody

CAT: 0223-57-248Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-248Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF) -alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity) .
NCBI Gene ID
5531
Swiss Prot
P60510
Accession Number
P60510
Host
Rabbit
Reactivity
Human
Immunogen
This PPP4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the Central region of human PPP4C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish, Bovine, Mouse, Rabbit, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
35 kDa
Fragment
Rabbit Ig
Symbol
PPP4C
NCBI Official Name
Serine/threonine-protein phosphatase 4 catalytic subunit
NCBI Organism
Homo sapiens
Background Reference 01
Lee, D.H., et al. Nat. Struct. Mol. Biol. 17 (3) :365-372 (2010)
Background Reference 02
Mourtada-Maarabouni, M., et al. Leuk. Res. 33 (11) :1539-1551 (2009)
Background Reference 03
Kumar, R.A., et al. PLoS ONE (2), E4582 (2009) :
Background Reference 04
Chen, G.I., et al. J. Biol. Chem. 283 (43) :29273-29284 (2008)
Other Product Names
Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C, Pp4, Protein phosphatase X, PP-X, PPP4C, PPP4, PPX
Tested Applications
WB, IHC-P
Protein ID
44888846
Physical Properties
Liquid

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