PPP4C Antibody

• Background:

  Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF) -alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity) .

• NCBI Gene ID:

  5531

• Swiss Prot:

  P60510

• Accession Number:

  P60510

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PPP4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the Central region of human PPP4C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Zebrafish, Bovine, Mouse, Rabbit, Rat, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  35 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PPP4C

• NCBI Official Name:

  Serine/threonine-protein phosphatase 4 catalytic subunit

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lee, D.H., et al. Nat. Struct. Mol. Biol. 17 (3) :365-372 (2010)

• Background Reference 02:

  Mourtada-Maarabouni, M., et al. Leuk. Res. 33 (11) :1539-1551 (2009)

• Background Reference 03:

  Kumar, R.A., et al. PLoS ONE (2), E4582 (2009) :

• Background Reference 04:

  Chen, G.I., et al. J. Biol. Chem. 283 (43) :29273-29284 (2008)

• Other Product Names:

  Serine/threonine-protein phosphatase 4 catalytic subunit, PP4C, Pp4, Protein phosphatase X, PP-X, PPP4C, PPP4, PPX

• Tested Applications:

  WB, IHC-P

• Protein ID:

  44888846

• Physical Properties:

  Liquid