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PPP6C Antibody

CAT: 0223-63-490Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-490Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PPP6C belongs to the PPP phosphatase family, PP-V subfamily. Reversible phosphorylation of proteins on serine and threonine residues is an important biochemical event that regulates a broad variety of intracellular processes. The phosphorylation state is determined by the well-controlled balance of activities of serine/threonine-specific protein kinases and protein phosphatases, including PPP6C. Expression levels are highest in testis, heart, and skeletal muscle and lowest in placenta, lung, and kidney. PPP6C can complement mutations in the S. cerevisiae Sit4 and S. pombe ppe1 genes, indicating that PPP6C is the functional homolog of yeast Sit4p and ppe1. Since Sit4p is required for the G1 to S transition of the cell cycle and ppe1 is involved in cell shape control and mitotic division, it has been suggested that PPP6C functions in cell cycle regulation.
NCBI Gene ID
5537
Swiss Prot
O00743
Accession Number
O00743
Host
Rabbit
Reactivity
Human
Immunogen
This PPP6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-305 amino acids from the C-terminal region of human PPP6C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
35 kDa
Fragment
Rabbit Ig
Symbol
PPP6C
NCBI Official Name
Serine/threonine-protein phosphatase 6 catalytic subunit
NCBI Organism
Homo sapiens
Background Reference 01
Yang, J., et al., EMBO J. 24 (1) :1-10 (2005) .
Background Reference 02
Zhou, G., et al., J. Biol. Chem. 279 (45) :46595-46605 (2004) .
Background Reference 03
Huang, S., et al., J. Biol. Chem. 279 (35) :36490-36496 (2004) .
Background Reference 04
Swingle, M.R., et al., J. Biol. Chem. 279 (32) :33992-33999 (2004) .
Other Product Names
Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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