TBCC Antibody

• Background:

  Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

• NCBI Gene ID:

  6903

• Swiss Prot:

  Q15814

• Accession Number:

  Q15814

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This TBCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human TBCC.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TBCC

• NCBI Official Name:

  Tubulin-specific chaperone C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hage-Sleiman, R., et al. BMC Cancer 10, 135 (2010) :

• Background Reference 02:

  Nature 447 (7145) :661-678 (2007)

• Background Reference 03:

  Mungall, A.J., et al. Nature 425 (6960) :805-811 (2003)

• Background Reference 04:

  Bartolini, F., et al. J. Biol. Chem. 277 (17) :14629-14634 (2002)

• Other Product Names:

  Tubulin-specific chaperone C, Tubulin-folding cofactor C, CFC, TBCC

• Tested Applications:

  WB

• Protein ID:

  313104020

• Physical Properties:

  Liquid